The Laws of Thermodynamics
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I You can't win.
II You can't break even.
III You can't get out of the game.
(Attributed to Allen Ginsberg, 1975)
Or in geekspeak:
$$ \Delta U = Q - W \\ dS = \frac{\delta Q}{T} \\ S - S_0 = k_B \ln(\Omega) $$
And that's only one of our topics this term, eh?